Antibody Innovation & Diagnostic Platform Development
At VexisBio Inc., we specialize in application-driven antibody discovery and translational in vitro diagnostic (IVD) development.
Our platform bridges biomarker science and commercial diagnostic execution — enabling biotech innovators to convert biological insight into scalable diagnostic solutions.
We focus on three integrated pillars:
• Antibody Discovery & Engineering
• Immunoassay & Biomarker Development
• IVD Kit Development & Commercialization Support
1. Antibody Discovery & Engineering
High-performance diagnostics begin with high-quality antibodies.
We develop antibodies engineered specifically for diagnostic applications, including ELISA and multiplex assay formats.
Capabilities
- Antigen design (protein, peptide, small molecule conjugates)
- Recombinant antigen production
- Hybridoma development
- Phage display screening
- High-affinity monoclonal antibody generation
- Epitope mapping & binning
- Antibody pair screening for sandwich ELISA
- Cross-reactivity testing
- Affinity ranking & optimization
- Scalable antibody production
Our screening strategy prioritizes assay performance, not just binding affinity.
2. Biomarker & Immunoassay Development
We transform validated antibodies into high-sensitivity, reproducible immunoassays designed for translational and commercial deployment.
Assay Development Services
- Custom sandwich ELISA development
- Competitive ELISA design
- Multiplex biomarker panels
- Low-abundance protein detection
- Cytokine and growth factor quantification
- Matrix compatibility optimization (serum, plasma, CSF)
- Signal-to-noise optimization
- Blocking and buffer refinement
Analytical Validation
- Limit of detection (LOD)
- Limit of quantification (LOQ)
- Linearity and dynamic range
- Precision (intra/inter assay)
- Specificity and cross-reactivity testing
- Reproducibility studies
Our development strategy integrates assay robustness and scalability from the earliest stages.
3. IVD Kit Development & Commercialization Support
We bridge the gap between functional assay and market-ready diagnostic kit.
Diagnostic Kit Development
- Assay-to-kit translation
- Reagent formulation optimization
- Antibody stabilization strategies
- Calibrator and control development
- Plate coating optimization
- Packaging configuration
- Accelerated stability studies
- Lot-to-lot consistency validation
OEM & Scale-Up Support
- White-label kit development
- Bulk antibody supply
- Process documentation support
- Technology transfer planning
- Long-term manufacturing alignment
Our focus is diagnostic-ready performance and scalable product design.
4. Neurodegenerative & Oncology Focus Areas
We support biomarker development programs in:
Neurodegenerative Diseases
- Alzheimer’s disease biomarkers
- Tau and amyloid-related targets
- Neurofilament light chain (NfL)
- Neuroinflammation markers
Oncology
- Tumor-associated antigens
- Cytokine panels
- Translational biomarker validation
- Companion diagnostic assay development
Inflammatory & Immune Profiling
- Growth factor quantification
- Immune activation panels
- Cytokine detection systems
5. Development Pathways
We structure projects based on stage and goals:
Feasibility Programs
Rapid biomarker and antibody performance validation.
Assay Development Programs
Comprehensive antibody pair screening and analytical optimization.
IVD Commercialization Programs
From validated assay to scalable diagnostic kit prototype.
Why Partner with VexisBio?
✔ Application-Driven Antibody Engineering
✔ Integrated Antibody-to-Kit Development
✔ Diagnostic-Focused Optimization
✔ Flexible Development Models
✔ Located in the San Diego Biotech Ecosystem
We operate as a strategic development partner — aligning antibody discovery with translational and commercial success.
Biotech Services at a Glance
Transparent pricing, ISO-styled QC, quick turnarounds (Request a quote).
Service Tables
| Scope | Typical Turnaround | Price (USD) |
|---|---|---|
| ELISA feasibility (pairing + LoD check) | 2–4 weeks | $3,000–$5,000 |
| Antibody pairing/screening (existing clones) | 1–3 weeks | $2,000–$6,000 / target |
| Antibody Discovery | 4-6 Months | Start from $30,000 |
| Assay optimization (linearity, precision) | 2–4 weeks | $4,000–$8,000 |
| Tech transfer (SOPs, layout, QC plan) | 1–2 weeks | $5,000–$8,000 |
Antibody Work
| Scope | Typical Turnaround | Price (USD) |
|---|---|---|
| Custom antibody development (RUO) | 10–14 weeks | $15,000–$22,000 |
| Conjugation pilot (1 label: HRP/biotin/fluor/gold/Eu/oligo) | 1–2 weeks | $2,000+ |
| Scale conjugation (2–5 mg input) + report | 1–2 weeks | $1,800–$3,500 / lot |
| Extra label on same clone | – | + $400–$700 |
| Customer-supplied antibody QC intake | – | $150 / vial |
Recombinant Proteins (E. coli)
| Scope | Typical Turnaround | Price (USD) |
|---|---|---|
| Cloning into provided vector | 3-7 business days | $800–$1,200 |
| Expression screen (3–6 conditions) | 1–2 weeks | $1,200-$2,000 |
| Purification (affinity± polish) | 3-7 business days | $800–$1,500 / run |
| Polishing (IEX/SEC) add-on | Per step | + $300–$600 |
| Endotoxin reduction workflow | Per lot | + $250–$600 |
| QC add-ons (BCA/HPLC/MS as available) | Per test | $100–$600 |
Nucleic Acid & Endotoxin
| Scope | Typical Turnaround | Price (USD) |
|---|---|---|
| DNA/RNA extraction (mini-batch ≤ 12) | 3–5 business days | $35–$85 / sample |
| Plasmid prep (Mini/Midi/Maxi) | 2–5 business days | $60 / $180 / $350 |
| Endotoxin-low plasmid option | – | + $60-$120 / prep |
| LAL endotoxin test (gel-clot/kinetic) | 2-3 business days | $150 / sample (5–19: $120; 20+: $100) |
Packaging, OEM & Consulting
| Scope | Typical Turnaround | Price (USD) |
|---|---|---|
| OEM/white-label fill/finish (RUO) | Per lot | $400–$900 + materials |
| Label/COA generation (per SKU) | – | $120-$240 |
| Scientific consulting / method review | As scheduled | $150 / hr |
| Custom bench work (outside bundles) | As scheduled | $120-$160 / hr + consumables |
Notes
- Usage: RUO only. Not for diagnostic use.
- Rush Service: Turnarounds reflect typical queues; rush service +15–25% if available.
- Logistics: Intake & logistics (receiving/biorepository) $50–$120 per shipment when applicable.
- Project Workflow: Multi-phase projects run Feasibility → Optimization → Scale-up → Tech transfer with QC gates.