Description

Target Information

MTBR‑Tau243 (microtubule-binding region containing residue 243) is a defined fragment of the tau protein derived from its microtubule‑binding region (MTBR), encompassing the sequence surrounding residue 243. This region has emerged as a highly specific biomarker for tau tangle pathology in Alzheimer’s disease. Elevated MTBR‑Tau243 levels in cerebrospinal fluid and plasma closely reflect the burden and progression of neurofibrillary tangles, a core hallmark of Alzheimer’s. Unlike phosphorylated tau markers that are more closely linked to amyloid‑related processes, MTBR‑Tau243 provides a direct measure of tau aggregation and associated cognitive decline. Its detection in biofluids offers valuable diagnostic differentiation from other neurodegenerative conditions and supports ongoing efforts to monitor disease progression and evaluate the impact of tau‑targeted therapeutic strategies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product Specifications

• Synonyms: microtubule-binding region containing residue 243
• Species Reactivity: Human
• Host/Isotype:  rabbit / IgG1, k
• Application: competitive ELISA, ELISA
• Cross Activity: No cross-reactivity against Tau peptide (aa 242-254), it shows good binding ability with Tau peptide (aa 243-254).
• Class:  Monoclonal
• Clone: SDT-2032-2/SDT-2032-13/SDT-2032-14
• Immunogen: Synthetic Peptide from Tau-F (P10636-8)
• Conjugate: Unconjugated
• Form: Lyophilized from 1 mg/mL in PBS, pH 7.3
• Storage conditions: -20°C, Avoid Freeze/Thaw Cycles
• Shipping conditions: Wet ice.