Application-Driven Antibody Development for Translational & IVD Programs
At VexisBio Inc., antibody engineering is at the core of our platform.
We develop high-affinity, application-validated antibodies optimized for diagnostic and translational use.
Our approach integrates antigen design, screening strategy, assay compatibility testing, and scale-up planning — ensuring antibodies are built not just for binding, but for real-world performance.
Our Antibody Development Workflow
- Antigen Design & Engineering
Successful antibody programs begin with intelligent antigen design.
We support:
• Full-length recombinant protein antigens
• Domain truncation and loop-domain selection
• Peptide antigen design
• Small molecule–carrier conjugates
• Epitope-focused antigen engineering
• Codon optimization for expression
We design antigens specifically for the intended application — ELISA, lateral flow, Western blot, or functional neutralization — not generic immunization.
- Recombinant Antigen Production
We produce high-quality antigens to drive robust immune responses and screening.
Capabilities include:
• Bacterial expression (E. coli)
• Insect cell expression (baculovirus system)
• Mammalian transient expression
• Inclusion body refolding
• Tag-based purification (His, GST, Fc)
• Size-exclusion chromatography polishing
Each antigen is validated for purity, structural integrity, and assay compatibility prior to immunization.
- Antibody Generation
We support multiple antibody discovery strategies depending on project goals:
Hybridoma Development
• Monoclonal antibody generation
• Isotype determination
• Affinity screening
• Stability validation
Phage Display & scFv Screening
• Library screening
• Clone selection
• Affinity ranking
• Functional validation
Our screening strategy is application-driven — focused on selecting antibodies that perform in diagnostic assay formats.
- Antibody Pair Screening for Diagnostics
Diagnostic performance requires carefully matched antibody pairs.
We provide:
• Sandwich ELISA pair screening
• Capture vs detection optimization
• Signal-to-noise evaluation
• Cross-reactivity testing
• Matrix compatibility testing (serum, plasma, etc.)
This is a major differentiator:
We engineer antibodies specifically for IVD assay compatibility.
- Epitope Mapping & Affinity Optimization
To support robust assay development and intellectual property positioning, we offer:
• Epitope binning
• Competitive binding analysis
• Affinity ranking
• Domain specificity testing
• Cross-species reactivity assessment
Where needed, we support affinity maturation and optimization strategies.
- IVD-Grade Antibody Production
For programs advancing toward commercialization, we provide:
• Scalable monoclonal production
• Batch reproducibility validation
• Purification & QC testing
• Stability studies
• Documentation support for regulatory submission
Our production strategy is designed for diagnostic kit integration.
Applications We Support
Our antibodies are developed for:
• High-sensitivity ELISA assays
• Multiplex biomarker panels
• Lateral flow diagnostic tests
• Western blot & research applications
• Companion diagnostic assay development
• Neurodegenerative biomarker detection
• Oncology biomarker panels
• Inflammatory & cytokine profiling
Industry Focus
We specialize in antibodies targeting:
• Neurodegenerative disease biomarkers
• Cancer-associated antigens
• Cytokines and growth factors
• Low-abundance serum proteins
• Emerging translational targets
Our platform is built to support biotech innovators developing next-generation diagnostic and biomarker solutions.
Why Partner with VexisBio?
✔ Application-Driven Design — Not Generic Antibody Production
✔ Diagnostic-Focused Screening Strategy
✔ Integrated Antigen to IVD Pipeline
✔ Flexible Development Models
✔ San Diego–Based Biotech Expertise
We operate as a strategic partner — aligning antibody development with downstream assay performance and commercialization strategy.
Engagement Models
Project-Based Antibody Development
Defined scope, milestone-based execution.
Antibody Pair Development Packages
Optimized for ELISA and diagnostic formats.
Long-Term Diagnostic Platform Collaboration
Co-development and scaling support.
Let’s Advance Your Antibody Program
Whether you are initiating target validation or building a diagnostic platform, VexisBio provides scalable, application-focused antibody development solutions.
📩 Contact Us to Discuss Your Project
📍 San Diego, California